| 2028 | Captain Zero: The Movie | (voice) |
| 2027 | Pierre the Pigeon-Hawk | (voice) |
| 2026 | Tribeca 25 | Self |
| 2025 | Leopardi & Co | Mildred |
| 2025 | ASALI: Power of the Pollinators | Galbanum (voice) |
| 2025 | Flower of the Dawn | Storyteller (voice) |
| 2025 | SNL50: The Homecoming Concert | Self |
| 2024 | Thom Browne: The Man Who Tailors Dreams | Self |
| 2024 | Like Tears in Rain | Self |
| 2024 | Super/Man: The Christopher Reeve Story | Self |
| 2024 | Atrabilious | Dr. Andrea Hart |
| 2024 | Group Therapy | Self (archive footage) |
| 2024 | Ezra | Jayne |
| 2024 | Babes | Dawn's Breasts |
| 2024 | Butterfly in the Sky | Self |
| 2024 | Outlaw Posse | Stagecoach Mary |
| 2024 | I'm "George Lucas": A Connor Ratliff Story | Self (archive footage) |
| 2023 | Oprah & The Color Purple Journey | Self |
| 2023 | The Color Purple | Midwife (uncredited) |
| 2023 | Three Trees | (Narration) |
| 2023 | Barry Humphries at the BBC | Self (archive material) |
| 2023 | Commitment to Life | Self (archive footage) |
| 2023 | Our Barbara | Self |
| 2022 | My Father's Dragon | Cat (voice) |
| 2022 | 20/20 Presents Black Panther: In Search of Wakanda | Self |
| 2022 | Till | Alma |
| 2022 | Music Is My Life: Joseph Shabalala and Ladysmith Black Mambazo | Self |
| 2022 | Is That Black Enough for You?!? | Self |
| 2022 | Cinderella: The Reunion, A Special Edition of 20/20 | Self |
| 2022 | Luck | Captain (voice) |
| 2022 | Tony Bennett: Forget Me Not | Self |
| 2022 | Bill Cosby: Walking Free | Self (archive footage) |
| 2022 | Whoopi Goldberg: The Winning Act | Self (archive footage) |
| 2022 | Soul of a Nation Presents: Screen Queens Rising | Self |
| 2021 | JFK Revisited: Through the Looking Glass | Self - Narrator (voice) |
| 2021 | The Most Magical Story on Earth: 50 Years of Walt Disney World | Self - Host |
| 2021 | Rita Moreno: Just a Girl Who Decided to Go for It | Self |
| 2021 | Sesame Street: 50 Years of Sunny Days | Self - Guest |
| 2020 | Billy Connolly: It’s Been a Pleasure... | Self |
| 2020 | Sarah Cooper: Everything's Fine | Whoopi Goldberg (voice) |
| 2020 | Walter Winchell: The Power of Gossip | Narrator |
| 2020 | The Great Work Begins: Scenes from Angels in America | Whoopi Goldberg |
| 2020 | A Virtual Princess Bride Reunion | The Mother / The Ancient Booer |
| 2020 | Chadwick Boseman: A Tribute for a King | Self - Co-host, "The View" |
| 2020 | My Darling Vivian | Self (archive footage) |
| 2020 | Feeding America Comedy Festival | Self |
| 2020 | Celebrating 25 Magical Years of Disney on Broadway | |
| 2020 | The Sit-In: Harry Belafonte Hosts The Tonight Show | Self |
| 2020 | Find Your Groove | Self |
| 2020 | The Paley Center Salutes Law & Order: SVU | (archive footage) |
| 2019 | Sesame Street's 50th Anniversary Celebration | Self |
| 2019 | The Most Magnificent Thing | Narrator (voice) |
| 2019 | Cracked Up | Self |
| 2019 | Charley Pride: I'm Just Me | Self |
| 2018 | Olympia | Self |
| 2018 | Nobody's Fool | Lola |
| 2018 | Trump @War | Self (archive footage) |
| 2018 | Scotty and the Secret History of Hollywood | Self (archive footage) |
| 2018 | The Gospel According to André | Self |
| 2018 | Furlough | Moms |
| 2018 | Mister Rogers: It's You I Like | Self |
| 2017 | Decorating Disney: Holiday Magic | Host |
| 2017 | The Problem with Apu | Self |
| 2017 | Sammy Davis, Jr.: I've Gotta Be Me | Self |
| 2017 | Yamasong: March of the Hollows | Yari (voice) |
| 2017 | 9/11 | Metzie |
| 2017 | Descendants 2 | Ursula (voice) (uncredited) |
| 2017 | The Truth Is in the Stars | Self |
| 2017 | Gilbert | Self |
| 2017 | A Very Sordid Wedding | Abernatha Coleman |
| 2017 | King of the Dancehall | Loretta Brixton |
| 2017 | Rio | Gayle Morgenstern |
| 2016 | X-Rated 2: The Greatest Adult Stars of All Time | Self |
| 2016 | Do I Look Like a Lady? (Comedians and Singers) | Self (archive footage) |
| 2016 | Too Hip for the Room: The Righteous Reign of Lord Buckley | Self |
| 2016 | The Beatles: Eight Days a Week - The Touring Years | Self |
| 2016 | 50 Years of Star Trek | Self |
| 2016 | Floyd Norman: An Animated Life | Herself |
| 2015 | Black Dog, Red Dog | Calliope |
| 2015 | The Three Stooges: Hey Moe! Hey Dad! | Self |
| 2015 | The Magic of the Diary of Anne Frank | Self |
| 2015 | Misery Loves Comedy | Self |
| 2014 | Top Five | Whoopi Goldberg |
| 2014 | Big Stone Gap | Fleeta Mullins |
| 2014 | Teenage Mutant Ninja Turtles | Bernadette Thompson |
| 2014 | A Day Late and a Dollar Short | Viola |
| 2013 | Kelly Clarkson's Cautionary Christmas Music Tale | Self |
| 2013 | Star Trek: The Next Generation - Redemption | Guinan |
| 2013 | Blackfish | Self |
| 2013 | Star Trek: The Next Generation - The Best of Both Worlds | Guinan (archive footage) |
| 2013 | Richard Pryor: Omit the Logic | Self |
| 2013 | Whoopi Goldberg Presents Moms Mabley | Self |
| 2013 | Why We Laugh: Funny Women | Self |
| 2013 | Miracle Rising: South Africa | Self |
| 2013 | The Contradictions of Fair Hope | Narrator |
| 2012 | 12-12-12 | The Concert for Sandy Relief | Self |
| 2012 | Radioman | Self |
| 2012 | Katy Perry: Part of Me | Self |
| 2012 | Paul Simon: Under African Skies | Self |
| 2012 | Python Legs! | |
| 2011 | The Muppets | Whoopi Goldberg |
| 2011 | Being Elmo: A Puppeteer's Journey | Narrator (voice) |
| 2011 | The Little Engine That Could | The Tower (voice) |
| 2011 | A Little Bit of Heaven | God |
| 2010 | For Colored Girls | Alice / White |
| 2010 | Teenage Paparazzo | Self |
| 2010 | 2Everything2Terrible2: Tokyo Drift | (archive footage) |
| 2010 | New York Street Games | Self |
| 2010 | Toy Story 3 | Stretch (voice) |
| 2010 | The Black List: Volume Three | Self |
| 2010 | See You in September | Lindsay's Therapist (uncredited) |
| 2009 | Square Roots: The Story of SpongeBob SquarePants | Self (archive footage) |
| 2009 | Journey to the Stars | Narrator (voice) |
| 2009 | Kambakkht Ishq | Whoopi Goldberg |
| 2009 | Star Trek: The Captain's Summit | Self |
| 2009 | Madea Goes to Jail | Self |
| 2009 | Stream | Jodi Quinn |
| 2008 | A Muppets Christmas: Letters to Santa | Taxi Driver |
| 2008 | Descendants | Red Flower (voice) |
| 2008 | Meerkat Manor: The Story Begins | Self - Narrator (voice) |
| 2008 | Snow Buddies | Miss Mittens (voice) |
| 2008 | Comic Relief: The Greatest... and the Latest | |
| 2007 | Nuremberg: The 60th Anniversary Director's Cut | Self |
| 2007 | Mr. Warmth: The Don Rickles Project | Self |
| 2007 | Annie Leibovitz: Life Through a Lens | Self |
| 2007 | The Sophisticated Misfit | Self |
| 2007 | Elton 60: Live At Madison Square Garden | Self |
| 2007 | Ghost Stories: The Making of a Classic | Self |
| 2007 | If I Had Known I Was a Genius | Mom |
| 2006 | Farce of the Penguins | Helen (voice) |
| 2006 | Comic Relief 2006 | |
| 2006 | Homie Spumoni | Thelma |
| 2006 | Everyone's Hero | Darlin' (voice) |
| 2006 | Doogal | Ermintrude (voice) |
| 2006 | The N Word | Self |
| 2005 | The Aristocrats | Self |
| 2005 | Jiminy Glick in Lalawood | Whoopi Goldberg |
| 2005 | Whoopi Goldberg: Back to Broadway | Herself / Fontaine / Lurleen / Crippled Lady |
| 2005 | Racing Stripes | Franny (voice) |
| 2004 | The Lion King 1½ | Shenzi (voice) |
| 2004 | Superbabies: Baby Geniuses 2 | Whoopi Goldberg |
| 2004 | The World of Nat King Cole | Self |
| 2004 | Pinocchio 3000 | Cyberina (voice) |
| 2004 | Uta Hagen's Acting Class | Self |
| 2004 | Sesame Street: Elmo's World: The Street We Live On! | Self (uncredited) |
| 2004 | TV in Black: The First Fifty Years | Self (archive footage) |
| 2003 | Richard Pryor: I Ain't Dead Yet, #*%$#@!! | Self |
| 2003 | New Jersey Devils Stanley Cup 2002-2003 Champions | Voice |
| 2003 | Declaration of Independence | Self |
| 2003 | Blizzard | Blizzard (voice) |
| 2003 | Pauly Shore Is Dead | Whoopi Goldberg |
| 2003 | Unchained Memories: Readings from the Slave Narratives | Narrator (voice) |
| 2003 | Good Fences | Mabel Spader |
| 2002 | Star Trek: Nemesis | Guinan (uncredited) |
| 2002 | It's a Very Merry Muppet Christmas Movie | Daniel's 'Boss' |
| 2002 | Madeline: My Fair Madeline | Miss Clavel (voice) |
| 2002 | The Hollywood Sign | Woman at Funeral (uncredited) |
| 2002 | Searching for Debra Winger | Self |
| 2002 | Showboy | Herself |
| 2002 | Making Rat Race | Herself |
| 2001 | The Making of 'A Charlie Brown Christmas' | Self - Hostess |
| 2001 | Call Me Claus | Lucy Cullins |
| 2001 | Rat Race | Vera Baker |
| 2001 | Beyond Tara: The Extraordinary Life of Hattie McDaniel | Self - Host |
| 2001 | Rescued from the Closet | Self |
| 2001 | Ghost: Remembering the Magic | Self |
| 2001 | Kingdom Come | Raynelle Slocumb |
| 2001 | Monkeybone | Death |
| 2001 | Golden Dreams | Califia, the Queen of California |
| 2001 | What Makes a Family | Terry Harrison |
| 2000 | Chuck Jones: Extremes and In-Betweens - A Life in Animation | Self |
| 2000 | Mary Pickford: A Life on Film | Self - Host / Narrator |
| 2000 | More Dogs Than Bones | Cléo |
| 2000 | The Adventures of Rocky & Bullwinkle | Judge Cameo (uncredited) |
| 2000 | Here's to You, Charlie Brown: 50 Great Years | Self - Host |
| 1999 | Girl, Interrupted | Valerie |
| 1999 | Jackie's Back! | Nurse Ethyl Washington Rue Owens (Jackie's Sister) |
| 1999 | The Deep End of the Ocean | Candy |
| 1999 | Alice in Wonderland | Cheshire Cat |
| 1999 | Our Friend, Martin | Mrs. Peck (voice) |
| 1999 | Alegría | Baby Clown |
| 1999 | Get Bruce! | Self |
| 1999 | Billy Connolly: Erect for 30 Years | |
| 1998 | The Rugrats Movie | Ranger Margaret (voice) |
| 1998 | A Knight in Camelot | Dr. Vivien Morgan |
| 1998 | Rudolph the Red-Nosed Reindeer: The Movie | Stormella (voice) |
| 1998 | Junket Whore | Self |
| 1998 | How Stella Got Her Groove Back | Delilah Abraham |
| 1998 | Jackie Chan: My Story | Self (uncredited) |
| 1998 | Titey | The Iceberg (voice) |
| 1998 | An Alan Smithee Film: Burn, Hollywood, Burn | Whoopi Goldberg |
| 1998 | Creating Ragtime | Host |
| 1997 | A Christmas Carol | Spirit of Christmas Present (voice) |
| 1997 | Cinderella | Queen Constantina |
| 1997 | Mother Goose: A Rappin' and Rhymin' Special | Mother Gooseberg (voice) |
| 1997 | In & Out | Whoopi Goldberg (uncredited) |
| 1997 | Pitch | Self |
| 1997 | Destination Anywhere | Cabbie |
| 1997 | In the Gloaming | Nurse Myrna |
| 1997 | Sports on the Silver Screen | Self (archive footage) |
| 1997 | Happy Birthday Elizabeth: A Celebration of Life | Self |
| 1996 | Ghosts of Mississippi | Myrlie Evers |
| 1996 | The Associate | Laurel Ayres |
| 1996 | Bogus | Harriet Franklin |
| 1996 | Bordello of Blood | Hospital Patient (uncredited) |
| 1996 | The Sunshine Boys | Nurse (uncredited) |
| 1996 | Eddie | Eddie Franklin |
| 1996 | The Good, The Bad, and the Beautiful | Self (archive footage) |
| 1996 | The Celluloid Closet | Self |
| 1995 | Theodore Rex | Katie Coltrane |
| 1995 | The Rolling Stones: Voodoo Lounge | Self - Hostess |
| 1995 | Comic Relief VII | Self - Host |
| 1995 | Moonlight and Valentino | Sylvie Morrow |
| 1995 | The Rolling Stones - Voodoo Lounge Uncut | Self - Host |
| 1995 | Bonnie Raitt Has Something to Talk About | Self |
| 1995 | Boys on the Side | Jane Deluca |
| 1994 | The Making of 'The Pagemaster' | Self (archive footage) |
| 1994 | The Pagemaster | Fantasy (voice) |
| 1994 | Star Trek: Generations | Guinan (uncredited) |
| 1994 | Corrina, Corrina | Corrina Washington |
| 1994 | The Little Rascals | Buckwheat's Mom |
| 1994 | The Lion King | Shenzi (voice) |
| 1994 | But... Seriously | Self (archive footage) |
| 1994 | Comic Relief VI | Self - Hostess |
| 1994 | Liberation | Narrator (voice) |
| 1994 | Sesame Street: The Best of Elmo | Self |
| 1993 | A Cool Like That Christmas | Mom / Irwin (voice) |
| 1993 | Sister Act 2: Back in the Habit | Deloris Van Cartier |
| 1993 | Naked in New York | Tragedy Mask on Theater Wall |
| 1993 | Sesame Street's 25th Birthday: A Musical Celebration | Self (segment "Monster in the Mirror") |
| 1993 | Aretha Franklin: Duets | Self |
| 1993 | National Lampoon's Loaded Weapon 1 | Billy York (uncredited) |
| 1993 | Made in America | Sarah Mathews |
| 1992 | The Magical World of Chuck Jones | Self |
| 1992 | Sarafina! | Mary Masembuko |
| 1992 | Metallica: A Year and a Half in the Life of Metallica | Self |
| 1992 | Wisecracks | |
| 1992 | Sister Act | Deloris Van Cartier / Sister Mary Clarence |
| 1992 | The Player | Detective Avery |
| 1992 | Defenders of Dynatron City | Ms. Megawatt (voice) |
| 1991 | House Party 2 | Professor (uncredited) |
| 1991 | Star Trek: 25th Anniversary Special | Self |
| 1991 | Rabbit Ears - Koi and the Kola Nuts | Narrator (voice) |
| 1991 | Chez Whoopi | Self - Host |
| 1991 | Soapdish | Rose Schwartz |
| 1990 | The Long Walk Home | Odessa Cotter |
| 1990 | Red Hot + Blue: A Tribute to Cole Porter | Self (uncredited) |
| 1990 | Ghost | Oda Mae Brown |
| 1990 | Comic Relief '90 | Self |
| 1990 | Happy Birthday, Bugs! 50 Looney Years | Self |
| 1990 | Celebrity Guide to Wine | Self |
| 1989 | Beverly Hills Brats | Self |
| 1989 | Whoopi Goldberg Presents: Billy Connolly | Herself |
| 1989 | Homer and Eddie | Eddie Cervi |
| 1989 | Hanna-Barbera's 50th | Self |
| 1989 | Kiss Shot | Sarah Collins |
| 1989 | Comic Relief III | |
| 1989 | The Debbie Allen Special | Self |
| 1988 | Pee-wee's Playhouse Christmas Special | Self |
| 1988 | Free to Be... a Family | Self |
| 1988 | Clara's Heart | Clara Mayfield |
| 1988 | Whoopi Goldberg's Fontaine... Why Am I Straight? | Fontaine |
| 1988 | Nelson Mandela 70th Birthday Tribute | Self |
| 1988 | The Telephone | Vashti Blue |
| 1988 | The Nelson Mandela 70th Birthday Concert | Self |
| 1987 | Fatal Beauty | Rita Rizzoli |
| 1987 | Funny, You Don't Look 200: A Constitutional Vaudeville | Lu Lu - Constitutional Caterer |
| 1987 | Happy 100th Birthday, Hollywood | Self |
| 1987 | Scared Straight!: 10 Years Later | Self - Host |
| 1987 | Burglar | Bernice 'Bernie' Rhodenbarr |
| 1987 | Carol, Carl, Whoopi and Robin | Self |
| 1987 | The Pointer Sisters: Up All Nite | Self |
| 1987 | Citizen Steve | Self - Actress |
| 1987 | Repairs | The Voice (voice) |
| 1986 | The Best of Comic Relief | Self |
| 1986 | Jumpin' Jack Flash | Terry Dolittle |
| 1986 | The Making of Captain EO | Self |
| 1986 | Bob Goldthwait: Don't Watch This Show | Self |
| 1986 | Doctor Duck's Super Secret All-Purpose Sauce | Self |
| 1985 | The Color Purple | Celie |
| 1985 | Whoopi Goldberg: Direct from Broadway | Self |
| 1985 | Night of 100 Stars II | Self |
| 1982 | Citizen | |
